Diabetes Glut4 And
Exercise, glut4, and skeletal muscle glucose uptake glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. glucose enters the muscle cell via facilitated diffusion through the glut4 glucose transporter which translocates from intracellular storage depots to the plasma m. Glut4 is in the family of solute carriers and is responsible for facilitating the transport glucose into the cells in response to insulin. for this reason, mutations in glut4 have been associated with type 2 diabetes. the glut4 gene has been mapped to the region 13 in the short arm of chromosome 17 (17p13). Insulin and amp-activated protein kinase (ampk) signal pathways are known to be involved in glucose uptake regulation, but the integration of signals between these two pathways in maintaining glucose homeostasis remains mysterious . insulin stimulates glucose uptake into skeletal muscle mainly via the translocation of glucose transporter 4 (glut4) to the plasma membr...